Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 25/28 (2006.01) C07C 65/15 (2006.01) C07D 237/00 (2006.01) C07D 249/00 (2006.01)

Patent

CA 2349700

There is disclosed 3-(5-methylisoxazol-3-yl)-6-(1-methyl-1,2,3-triazol-4- yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine in the form of a dihydrate, a dehydrate of the dihydrate and a pentahydrate, pharmaceutical compositions comprising the forms, the use of the forms for enhancing cognition, processes for producing the forms, their incorporation in pharmaceutical compositions comprising pamoate ions and the use of such ions for solubilizing neutral molecules.

Cette invention se rapporte au composé 3-(5-méthylisoxazol-3-yl)-6-(1-méthyl-1,2,3-triazol-4-yl)méthyloxy-1,2,4-triazolo[3,4-a]phtalazine sous la forme d'un dihydrate, d'un déshydrate de ce dihydrate et d'un pentahydrate; à des compositions pharmaceutiques contenant ces formes, à l'utilisation de ces formes pour améliorer les facultés cognitives, à des procédés de production de ces formes, à leur incorporation dans des compositions pharmaceutiques contenant des ions pamoate et à l'utilisation de ces ions pour solubiliser des molécules neutres.

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