Angiotensin ii receptor blocker derivatives

Details Angiotensin ii receptor blocker derivatives Angiotensin ii receptor blocker derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/41 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) C07D 257/04 (2006.01) C07D 403/04 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2534451

Nitrooxy derivatives of the angiotensin-II receptor blockers Iosartan vaalsartan, candesartan, telmisartan, eprosartan and olmesartan and related compounds of formula (I): R-(Y-ONO2)s wherein R is of formula (II) or (III): R0 is e.g: and R1 is: (IIa), (IIb), (IIc), (IId) or (IIe).

L'invention concerne des nitrodérivés de bloqueur du récepteur de l'angiotensine II de formule générale (I) : R-(Y-ONO¿2?)¿s?, présentant une activité pharmacologique étendue et une tolérabilité améliorée. Ces nitrodérivés peuvent être utilisés pour le traitement de maladies cardiovasculaires, rénales et hépatiques chroniques et de processus inflammatoires.

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