Piperidine or 8-aza-bicyclo¬3.2.1|oct-3-yl derivatives...

Details Piperidine or 8-aza-bicyclo¬3.2.1|oct-3-yl derivatives... Piperidine or 8-aza-bicyclo¬3.2.1|oct-3-yl derivatives...

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61K 31/46 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 451/04 (2006.01)

Patent

CA 2479887

The invention provides a compound of formula (I) wherein A, R1, R2, R3, R3a, R4, R4a, R5, and R6 are as defined; or a pharmaceutically acceptable salt thereof or a solvate thereof; compositions containing these compounds,processes for preparing them and their use as modulators of chemokine activity (for example CCR5 activity).

La présente invention concerne un composé représenté par la formule générale (I) ou l'un de ses sels ou solvats pharmaceutiquement admis. Dans cette formule (I), les A, R?1¿, R?2¿, R?3¿, R?3a¿, R?4¿, R?4a¿, R?5¿, et R?6¿ sont tels que défini. L'invention concerne également des compositions contenant ces composés, des procédés pour les élaborer, et leur utilisation comme modulateurs de l'activité de la chimiokine (par exemple l'activité CCR5).

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