Benzoylpyridazines

Details Benzoylpyridazines Benzoylpyridazines

C - Chemistry, Metallurgy

07

D

C07D 237/04 (2006.01) A61K 31/50 (2006.01) A61P 37/00 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2378595

The invention relates to benzoyl derivatives of formula (I) and the physiologically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5 and R6 have the meanings cited in Claim 1. Said derivatives inhibit phosphodiesterase IV and can be used to treat allergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, auto-immune diseases such as rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumoral growth or tumoral metastases, septicemia, memory defects, atherosclerosis and AIDS.

L'invention concerne des dérivés benzolpyridazine correspondant à la formule (I), ainsi que leurs sels et solvates ne présentant aucun inconvénient sur le plan physiologique. Dans ladite formule (I), R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et R?5¿ ont les significations données dans la revendication 1. Ces dérivés ont un effet inhibiteur de la phosphodiestérase IV et peuvent être utilisés pour traiter des maladies allergiques, l'asthme, la bronchite chronique, la dermatite atopique, le psoriasis et d'autres maladies de la peau, des maladies inflammatoires, des maladies auto-immunes, par exemple l'arthrite rhumatoïde, la sclérose en plaques, la maladie de Crohn, le diabète sucré ou la recto-colite ulcéro-hémorragique, l'ostéoporose, les réactions de rejet d'implants, la cachexie, la croissance tumorale ou les métastases tumorales, la septicémie, les troubles de la mémoire, l'athérosclérose et le sida.

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