Novel 4-aminopiperidine derivatives as plasmepsin ii inhibitors

Details Novel 4-aminopiperidine derivatives as plasmepsin ii inhibitors Novel 4-aminopiperidine derivatives as plasmepsin ii inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61K 31/4523 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2587888

Novel substituted 4-aminopiperidine derivatives of the formula I: wherein n, R1 , Y, (A) , and (B) are as defined in claim 1 and optically pure enantiomers, mixtures of enantiomers, racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates and meso-forms, as well as salts and solvent complexes of such compounds, and morphological forms, that exhibit useful parasite aspartic proteases inhibiting properties and can thus be used in the form of pharmaceutical compositions as antimalarial medicines.

L'invention concerne de nouveaux dérivés de 4-aminopipéridine substitués de formule I, dans laquelle n, R<SUP>1</SUP>, Y, (A) et (B) sont tels que définis dans la revendication 1, ainsi que des énantiomères optiquement purs, des mélanges d'énantiomères, des racémates, des diastéréomères, des mélanges de diastéréomères, des racémates diastéréomériques, des mélanges de racémates diastéréomériques et des formes méso, ainsi que des sels et des complexes de solvants desdits composés, et des formes morphologiques, présentant des propriétés utiles inhibitrices de protéases aspartiques parasitaires et pouvant ainsi être utilisés sous la forme de compositions pharmaceutiques en tant qu'antipaludiques.

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