Fluoro substituted cycloalkanoindoles and their use as...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/80 (2006.01) A61K 31/403 (2006.01) A61P 43/00 (2006.01) C07D 209/88 (2006.01)

Patent

CA 2471952

Fluoro substituted cycloalkanoindole derivatives of formula (1) and pharmaceutically acceptable salts thereof, wherein n is 0 or 1; m is 1, 3 or 3; R1 is H, C1-C3 alkyl, halogenated C1-C3 alkyl or cyclopropyl; R2 is 4-chlorophenyl or 2,4,6-trichlorophenyl are an-tagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.

L'invention concerne des dérivés cycloalkanoindoles à substitution fluor qui constituent des antagonistes de la prostaglandine et qui peuvent donc être utilisés pour le traitement de maladies médiées par la prostaglandine.

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