Human tumor necrosis factor receptor tr10

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C12P 21/06 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2372246

The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.

La présente invention concerne une nouvelle protéine, la TR10, qui constitue un membre de la superfamille des récepteurs de facteur de nécrose tumorale (TNF) et de la sous-famille de récepteur TRAIL . En particulier, cette invention concerne des molécules d'acide nucléique isolées codant la protéine humaine TR10. En outre, cette invention concerne des polypeptides TR10, des vecteurs, des cellules hôtes ainsi que des méthodes de recombinaison pour les produire. Enfin, cette invention concerne des procédés de criblages utilisées pour identifier les agonistes et les antagonistes de l'activité de TR10.

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