Production of human recombinant collagen in the milk of...

Details Production of human recombinant collagen in the milk of... Production of human recombinant collagen in the milk of...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A23C 9/00 (2006.01) A23C 9/20 (2006.01) A23J 1/20 (2006.01) A23J 3/06 (2006.01) C07K 1/14 (2006.01) C07K 14/78 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2152047

Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mamals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.

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