Tris carbamic acid esters: inhibitors of cholesterol absorption

Details Tris carbamic acid esters: inhibitors of cholesterol absorption Tris carbamic acid esters: inhibitors of cholesterol absorption

C - Chemistry, Metallurgy

07

D

C07D 211/46 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 207/12 (2006.01) C07D 223/08 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 405/14 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2128116

ABSTRACT Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are therefore implicates in the inhibition of absorption of cholesterol and Thus can lower serum cholesterol levels. Compounds of the formula: Image u here Z is Z is -Ar1,-Ar1-Ar2,-Ar1-O-Ar2,Ar1-S-Ar2,Ar1-O-?-Ar2, -Ar1-?-O-Ar2, -Ar1-?-Ar2, -Ar1-(CH2)1-20-Ar2, -Ar1-(CH2)1-20-O-Ar2, -Ar1-O-(CH2)1-20-Ar2 or-Ar1-(CR=CR)1-3-Ar2, -AR1-NR7-AR2 and A is a linking group inhibit the enzymes CEH and/or ACAT (in vitro) and inhibit absorption of cholesterol.

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