A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 39/09 (2006.01) C07K 16/12 (2006.01) C12N 5/12 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2448506
Dental caries in man may be prevented or treated by oral ingestion of human or humanized murine monoclonal IgG and IgM antibodies that bind to surface antigens of cariogenic organisms, such asS. mutans. The genetically engineered monoclonal antibodies engage the effector apparatus of the human immune system when they bind to cariogenic organisms, resulting in their destruction. In a preferred embodiment, monoclonal antibodies to cariogenic organisms are produced by edible plants, including fruits and vegetables, transformed by DNA sequences that code on expression for the desired antibodies. The antibodies are applied by eating the plants.
L'invention concerne la prévention ou le traitement des caries dentaires chez l'être humain, par absorption (voie orale) d'anticorps monoclonaux humains ou murins humanisés IgG et IgM qui se lient avec les antigènes de surface d'organismes cariogènes du type S.mutans. Lesdits anticorps issus du génie génétique sollicitent l'appareil effecteur du système immunitaire humain au moment où ils se lient avec les organismes cariogènes, entraînant la destruction de ces derniers. En mode de réalisation préféré, les anticorps considérés sont issus de végétaux comestibles, y compris les fruits et légumes, transformés par le biais de séquences d'ADN qui codent l'expression des anticorps souhaités. L'application des anticorps s'effectue par consommation des végétaux en question.
Anderson Maxwell H.
Chen Li
Morrison Sherie L.
Shi Wenyuan
Trinh Kham
C3 Scientific Corporation
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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