Protein having anticoagulant properties

Details Protein having anticoagulant properties Protein having anticoagulant properties

C - Chemistry, Metallurgy

12

N

530/7.1, 195/1.2

C12N 15/15 (2006.01) A61K 38/55 (2006.01) C07K 1/36 (2006.01) C07K 14/81 (2006.01) C12N 15/11 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2024697

9727P/5977A 17972IB TITLE OF THE INVENTION PROTEINS HAVING ANTICOAGULANT PROPERTIES ABSTRACT OF THE DISCLOSURE Proteins which specifically inhibit coagula- tion Factor Xa. The inhibitors, which do not inhibit Factor VIIa, kallikrein, trypsin, chymotrypsin, thrombin, urokinase, tissue plasminogen activator, plasmin, elastase, Factor XIa or S. aureus V8 protease, are polypeptides of 60 amino acid residues. The inhibitors may be purified from Ornithodoros moubata extract, synthesized, or produced using a recombinant DNA yeast expression system.

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