C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 65/329 (2006.01) C08G 65/00 (2006.01) C08G 65/331 (2006.01)
Patent
CA 2497980
A method is provided for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid or ester thereof. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid. In addition, the invention provides water-soluble polymers bearing a terminal carboxylic acid or ester thereof, intermediates and reagents useful in carrying out the method, as well as gels, pharmaceutical formulations, conjugates related to the described water-soluble polymer derivatives.
L'invention concerne un procédé permettant de préparer des dérivés de polymères hydrosolubles comportant un acide carboxylique terminal ou un ester de celui-ci. Le procédé décrit dans cette invention consiste à hydrolyser un orthoester d'un polymère hydrosoluble afin d'obtenir l'acide correspondant. En outre, cette invention concerne des polymères hydrosolubles comportant un acide carboxylique terminal ou un ester de celui-ci, des produits intermédiaires et des réactifs servant à la mise en oeuvre dudit procédé. Cette invention concerne également des gels, des préparations pharmaceutiques, des conjugués associés aux dérivés de polymères hydrosolubles décrits dans cette invention.
Gowling Lafleur Henderson Llp
Nektar Therapeutics
Nektar Therapeutics Al Corporation
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