Process for the preparation of an hiv protease inhibiting...

Details Process for the preparation of an hiv protease inhibiting... Process for the preparation of an hiv protease inhibiting...

C - Chemistry, Metallurgy

07

D

C07D 277/30 (2006.01) C07D 277/28 (2006.01)

Patent

CA 2219983

Processes are disclosed for the preparation of (2S, 3S, 5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4- thiazolyl)methyl)amino)carbonyl)--L-valinyl)amino)-2-(N-((5- thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane or an acid addition salt thereof and (2S, 3S, 5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4thiazolyl)methyl)amino)carbonyl)-D- valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino- 1,6-diphenyl-3-hydroxyhexane or an acid addition salt thereof.

L'invention porte sur des procédés de préparation du (2S,3S,5S)-5-(N-(N-((N-méthyl-N-((2-isopropyl-4-thiazolyl)méthyl)amino)carbonyl)-L-valinyl)amino)-2-(N-((5-thiazolyl)méthoxycarbonyl)amino-1,6-diphényl-3-hydroxyhexane ou d'un sel d'addition d'acide de ce composé et du (2S,3S,5S)-5-(N-(N-((N-méthyl-N-((2-isopropyl-4-thiazolyl)méthyl)amino)carbonyl)-D-valinyl)amino)-2-(N-((5-thiazolyl)méthoxycarbonyl)amino-1,6-diphényl-3-hydroxyhexane ou d'un sel d'addition d'acide de ce composé.

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