Process for preparing a radiopharmaceutical composition

Details Process for preparing a radiopharmaceutical composition Process for preparing a radiopharmaceutical composition

A - Human Necessities

61

K

A61K 51/08 (2006.01)

Patent

CA 2054263

A process for preparing a radiopharmaceutical composition comprising a technetium 99m chelate complex, comprises the steps of: (1) mixing (a) HSCH2CO-NHCH2CO-NHCH2CO-NHCH2COOH (mercaptoacetylglycylglycylglycine, MAG3), (b), a water-soluble reducing agent, (c) a water-soluble stabilizing agent in an amount of not less than 70 mol per 1 mol of the water-soluble reducing agent and (d) a pertechnetate at a pH of about 8 to 11; and (2) heating the resultant mixture at a temperature of about 90 to 140°C. This process removes any troublesome labelling operation at the diagnostic site and hence relieves practitioners from exposure to radiation during the labelling operation.

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