Modified rapid expansion methods ("modified-rem") for in...

Details Modified rapid expansion methods ("modified-rem") for in... Modified rapid expansion methods ("modified-rem") for in...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2247131

The present invention provides a modified rapid expansion method (termed "low- PBMC-REM" or "modified-REM"), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes, without using the large excesses of peripheral blood mononuclear cells (PBMC) or EBV-transformed lymphoblastoid cells (LCL) characteristic of high-PBMC-REM. Clonal expansions of greater than 500-fold can be achieved within a single stimulation cycle of about 8-14 days.

L'invention porte sur un procédé modifié d'expansion rapide (dit PBMC-REM basse ou REM modifié), permettant de produire rapidement d'importantes quantités de lymphocytes T y compris des lymphocytes T cytolytiques et auxiliaires sans recourir à de forts excès de globules sanguins périphériques mononucléaires (PBMC) ou de cellules lymphoblastoïdes (LCL) à transformation EBV, caractéristiques de la PBMC-REM haute. Des expansions clonales supérieures à 500 fois peuvent être atteintes au cours d'un seul cycle de stimulation d'environ 8 à 14 jours.

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