A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/136 (2006.01) A61K 31/01 (2006.01) A61K 31/015 (2006.01)
Patent
CA 2691132
The subject invention pertains to materials and methods for the prevention and treatment of disease conditions associated with oxidative stress or a compromised reducing environment, including inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Another aspect of the subject invention concerns compositions formulated for administration as an enema. In one embodiment, a composition suitable for administration as an enema comprises an effective amount of 5-ASA and a steroid such as budesonide or hydrocortisone. The subject invention also concerns compositions formulated for oral administration. In one embodiment, a composition comprises alpha-lipoic acid, and/or N-acetyl-L- cysteine (N-A-C), and/or L-glutamine. The alpha-lipoic acid can be racemic alpha-lipoic acid, R-lipoic acid, or R-dihydro-lipoic acid. Methods of the invention include administration of compounds or compositions of the invention. In one embodiment, compounds or compositions of the invention are rectally instilled in a patient. In another embodiment, compounds or compositions are orally administered. The subject invention also concerns methods for screening for, assessing risk of developing, and/or diagnosing conditions associated with oxidative stress, such as ulcerative colitis and other inflammatory bowel disorders. The subject invention pertains to materials and methods for the prevention and treatment of disease conditions associated with oxidative stress or a compromised reducing environment, including inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Another aspect of the subject invention concerns compositions formulated for administration as an enema. In one embodiment, a composition suitable for administration as an enema comprises an effective amount of 5-ASA and a steroid such as budesonide or hydrocortisone. The subject invention also concerns compositions formulated for oral administration. In one embodiment, a composition comprises alpha-lipoic acid, and/or N-acetyl-L- cysteine (N-A-C), and/or L-glutamine. The alpha-lipoic acid can be racemic alpha-lipoic acid, R-lipoic acid, or R-dihydro-lipoic acid. Methods of the invention include administration of compounds or compositions of the invention. In one embodiment, compounds or compositions of the invention are rectally instilled in a patient. In another embodiment, compounds or compositions are orally administered. The subject invention also concerns methods for screening for, assessing risk of developing, and/or diagnosing conditions associated with oxidative stress, such as ulcerative colitis and other inflammatory bowel disorders.
La présente invention porte sur des matières et des procédés pour la prévention et le traitement d'états de maladie associés à un stress oxydatif ou à un environnement réducteur compromis, comprenant les maladies intestinales inflammatoires telles que la maladie de Crohn et la colite ulcéreuse. Un autre aspect de la présente invention concerne des compositions formulées pour une administration comme lavement. Dans un mode de réalisation, une composition appropriée à une administration sous forme de lavement comprend une quantité efficace de 5-ASA et un stéroïde tel que le budésonide ou l'hydrocortisone. La présente invention concerne également des compositions formulées pour une administration orale. Dans un mode de réalisation, une composition comprend de l'acide alpha-lipoïque et/ou de la N-acétyl-L-cystéine (N-A-C) et/ou de la L-glutamine. L'acide alpha-lipoïque peut être un acide alpha-lipoïque racémique, un acide R-lipoïque ou un acide R-dihydro-lipoïque. Les procédés de l'invention comprennent l'administration de composés ou de compositions de l'invention. Dans un mode de réalisation, des composés ou compositions de l'invention sont instillés par voie rectale dans un patient. Dans un autre mode de réalisation, des composés ou compositions sont administrés par voie orale. La présente invention concerne également des procédés pour cribler, pour évaluer un risque de développement et/ou diagnostiquer des états associés à un stress oxydatif, tels qu'une colite ulcéreuse et d'autres troubles intestinaux inflammatoires.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Pravda Jay
LandOfFree
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