Small molecule inhibitors of rotamase enzyme activity

Details Small molecule inhibitors of rotamase enzyme activity Small molecule inhibitors of rotamase enzyme activity

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 38/05 (2006.01) A61P 25/00 (2006.01) C07D 207/16 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2206799

This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Cette invention concerne des composés neurotrophiques d'ester de N-glyoxylpropyle présentant une affinité envers des immunophilines de type FKBP, ainsi que leur préparation et leur utilisation en qualité d'inhibiteurs d'activité enzymatique associée à des protéines d'immunophiline, et notamment en qualité d'inhibiteurs de l'activité enzymatique de la peptidylpropyl-rotamase ou isomérase.

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