A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/00 (2006.01) A61K 31/713 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2592172
The present invention relates to the identification of new drug targets for therapy of disorders including cancer. In particular, the present invention relates to inhibition of the E3 ubiquitin ligase, Itch, as a means for treating disorders. Furthermore, the present invention relates to the regulation of p63 and p73 stability in cells. In particular, the invention relates to the modulation of the regulation of p63 and p73 stability in cells through modulation of the expression or activity of Itch. Moreover, the invention relates to the use of Itch as a target for the development of agents capable of modulating p63 or p73 stability and especially agents capable of modulating the interaction of Itch and p63 or p73. Such agents may be useful in therapeutic applications including cancer treatment and modulation of skin differentiation.
La présente invention porte sur l'identification de nouvelles cibles de médicaments utilisées dans le traitement de maladies telles que le cancer. L'invention porte notamment sur l'inhibition de la ligase ubiquitine E3, Itch, comme moyen de traitement des maladies. L'invention porte, en outre, sur la régulation de la stabilité de p63 et p73 dans des cellules. L'invention porte, en particulier, sur la modulation de la régulation de la stabilité de p63 et p73 par modulation de l'expression ou de l'activité de Itch. L'invention porte, en outre, sur l'utilisation de Itch comme cible dans le développement d'agents capables de moduler la stabilité de p63 ou p73, et notamment d'agents capables de moduler l'interaction de Itch et p63 ou p73. Ces agents peuvent être utiles dans des applications thérapeutiques incluant le traitement du cancer et la modulation de la différenciation de la peau.
Melino Gennaro
Rossi Mario
Salomoni Paolo
Kirby Eades Gale Baker
Medical Research Council
LandOfFree
Modulators of itch ubiquitinase activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulators of itch ubiquitinase activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulators of itch ubiquitinase activity will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1720206