Piperazinylcarbonylquinolines and -isoquinolines

Details Piperazinylcarbonylquinolines and -isoquinolines Piperazinylcarbonylquinolines and -isoquinolines

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 215/48 (2006.01) C07D 217/26 (2006.01)

Patent

CA 2434773

A compound of formula I (see formula I) in which: R1 is a phenyl radical which is unsubstituted or substituted by R3 and/or R4; R2 is a quinolinyl or isoquinolinyl radical; R3 is H; R4 is Hal; alk is ethylene; and Hal is F, Cl, Br or I; or a physiologically acceptable salt thereof is a potent 5-HT2A antagonist and is suitable for the treatment of psychoses, schizophrenia, depression, neurological disorders, memory disorders, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders, such as bulimia, anorexia nervosa, premenstrual syndrome and/or for positively influencing obsessive-compulsive disorder (OCD).

L'invention porte sur des composés représentés par la formule I, dans laquelle R?1¿, R?2¿ et alk sont tels que définis dans la revendication 1. Ces composés sont des antagonistes puissants et conviennent au traitement de psychoses, de la schizophrénie, de la dépression, des troubles neurologiques, des troubles de la mémoire, de la maladie de Parkinson, de la sclérose latérale amyotrophique, de la maladie d'Alzheimer, de la maladie d'Huntington, de troubles alimentaires, tels que la boulimie, l'anorexie nerveuse, des syndromes prémenstruels et/ou à l'influence positive des troubles obsessionnels compulsifs (TOC).

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