Methods and compositions for the inhibition of cathepsins

Details Methods and compositions for the inhibition of cathepsins Methods and compositions for the inhibition of cathepsins

A - Human Necessities

61

K

A61K 38/57 (2006.01) A61K 38/55 (2006.01) C07K 14/81 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2514395

Methods and compositions for modulating cell death by contacting a cell with an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. In addition, methods of treating a subject by providing the subject a composition that includes an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. The Spi2A polypeptide and Spi2A polypeptide equivalent can be delivered to the subject using gene therapy techniques. The subject can be a patient with a disease associated with an abnormal rate of cell death, such as septic shock or myocardial infarction. Also disclosed are methods of preparing and storing donor granulocytes, involving contacting the donor granulocytes with an Spi2A polypeptide or an Spi2A polypeptide equivalent.

La présente invention concerne des procédés et des compositions pour moduler la mort cellulaire par mise en contact d'une cellule avec un polypeptide Spi2A ou un équivalent de polypeptide Spi2A. Elle concerne également des procédés pour traiter un sujet, qui consistent à administrer à ce sujet une composition comprenant un polypeptide Spi2A ou un équivalent de polypeptide Spi2A. Ce polypeptide Spi2A ou cet équivalent de polypeptide Spi2A peut être administré au sujet au moyen de techniques de thérapie génique. Le sujet peut être un patient atteint d'une maladie qui est associée à un taux anormal de mort cellulaire, telle qu'un choc septique ou un infarctus du myocarde. En outre, cette invention concerne des procédés pour préparer et conserver des granulocytes donneurs, qui consistent à mettre en contact les granulocytes donneurs avec un polypeptide Spi2A ou un équivalent de polypeptide Spi2A.

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