Tetrazol benzofurancarboxamides with p13k activity as...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/12 (2006.01) A61K 31/41 (2006.01) A61P 3/10 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2527934

The present invention provides benzofurans of Formula (I): wherein R1, R2, R3, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I).

L'invention se rapporte à des benzofuranes selon la formule (I): dans laquelle R?1¿, R?2¿, R?3¿, et L ont l'une quelconque des valeurs définies dans la spécification, ainsi qu'à leurs sels pharmaceutiquement acceptables, ces composés étant utiles comme agents dans le traitement de maladies et états tels que les maladies inflammatoires, les maladies cardio-vasculaires et les cancers. Des compositions pharmaceutiques comprenant un ou plusieurs composés de la formule (I) sont également décrites.

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