Piperidine and piperazine derivatives

Details Piperidine and piperazine derivatives Piperidine and piperazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/36 (2006.01) C07D 209/08 (2006.01) C07D 211/54 (2006.01) C07D 213/70 (2006.01) C07D 217/02 (2006.01) C07D 233/84 (2006.01) C07D 271/12 (2006.01) C07D 285/14 (2006.01) C07D 295/22 (2006.01) C07D 295/26 (2006.01) C07D 307/91 (2006.01) C07D 333/34 (2006.01) C07D 333/62 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2396007

The invention relates to compounds of formula (I), wherein R1, R2, X, Y and alk are defined as per claim 1, are potent 5-HT2A antagonists and are suitable for treating psychosis, schizophrenia, depression, neurological disorders, impaired memory, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders, such as bulimia and anorexia nervosa, premenstrual syndrome and/or for positively influencing compulsive behaviour (obsessive-compulsive disorder, OCD).

L'invention concerne des composés de formule (I) dans laquelle R?1¿, R?2¿, X, Y et alk ont les significations données dans la revendication 1. Ces composés sont de puissants antagonistes 5-HT¿2A? et sont appropriés pour le traitement de psychoses, schizophrénie, dépressions, troubles neurologiques, troubles de la mémoire, maladie de Parkinson, sclérose latérale amyotrophique, maladie d'Alzheimer, troubles d'alimentation tels que boulimie et anorexie mentale, syndrome prémenstruel et/ou pour influencer positivement un comportement compulsif (trouble obsessionnel compulsif, OCD).

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