C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/90 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2593166
The present invention relates to fluorinated 2-aminomethylquinazolinone derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des dérivés fluorés de 2-aminométhylquinazolinone utilisés dans le traitement des maladies cellulaires prolifératives et des troubles associés à l'activité de la kinésine KSP, et dans l'inhibition de la kinésine KSP. L'invention concerne également des compositions contenant lesdits composés, ainsi que des méthodes d'utilisation de celles-ci dans le traitement du cancer chez les mammifères.
Coleman Paul J.
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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