A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 31/16 (2006.01) A61L 31/10 (2006.01) C09D 7/14 (2006.01)
Patent
CA 2596960
A method of modulating drug release from coated substrates by modulating the drying rate of the coatings on the substrates. Each coating is a mixture of a polymer, a solvent, and drug and the method includes modulating the release rate of the drug particles from the outer surface of the coatings by drying the solvent of each of the mixtures at different drying rates. A decrease in the drying rate of the solvent increases the initial release rate of the drug and an increase in the drying rate of the solvent decreases the initial release rate of the drug.
L'invention concerne un procédé de modulation de la libération d'un médicament à partir d'un substrat enrobé, par modulation de la vitesse de séchage des enrobages sur les substrats. Chaque enrobage est un mélange constitué par un polymère, un solvant et un médicament. Le procédé selon l'invention consiste à moduler la vitesse de libération des particules de médicament à partir de la surface extérieure des enrobages, par séchage du solvant de chacun des mélanges à une vitesse de séchage différente. Une réduction de la vitesse de séchage du solvant augmente la vitesse de libération initiale du médicament, et une augmentation de la vitesse de séchage du solvant réduit la vitesse de libération initiale du médicament.
Boston Scientific Limited
Mccarthy Tetrault Llp
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