Use of interferon alpha 5 in the treatment of viral liver...

Details Use of interferon alpha 5 in the treatment of viral liver... Use of interferon alpha 5 in the treatment of viral liver...

A - Human Necessities

61

K

A61K 38/21 (2006.01)

Patent

CA 2335645

The invention relates to the use of interferon alpha 5 in the treatment of viral hepatopathies. The invention describes the reduced synthesis of IFN.alpha.5 in the livers of patients with hepatitis C in comparison to healthy livers. The sub-type of IFN expressed in said healthy livers corresponded only to the subtype alpha 5 in comparison with the different sub-types expressed in ill livers. The sequence SEQ ID NO:l shows the partial sequence of cDNA corresponding to IFN.alpha.5. These significant differences between the expression patterns of some livers an others demonstrate the importance of the use of such interferon sub-type in the fabrication of compositions useful in the treatment of viral hepatopathies. The invention discloses in details such utilization in different forms and processes, including those which use the production of recombinant proteins from sequences of the type SEQ ID NO:1.

L'invention concerne l'utilisation de l'interféron alpha 5 dans le traitement des hépatophaties virales et la synthèse réduite d'IFN.alpha.5 dans les foies de patients souffrant d'hépatite C en comparaison avec les foies sains. Le sous-type d'IFN exprimé dans lesdits foies sains s'est avéré ne correspondre qu'au sous-type alpha 5 parmi les différents sous-types exprimés dans les foies malades. Dans la SEQ ID NO:1 on montre la séquence partielle d'ADN complémentaire correspondant à IFN.alpha.5. Les différences significatives entre les modèles d'expression de divers foies mettent en évidence l'importance de l'utilisation de ce sous-type d'interféron dans la fabrication de compositions utiles dans le traitement d'hépatopathies d'origine virales. L'utilisation est détaillée sous différentes formes et procédés, y compris ceux qui utilisent la production de protéines recombinantes à partir de séquences de type SEQ ID NO:1.

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