Cell-specific retroviral vectors with antibody domains and...

Details Cell-specific retroviral vectors with antibody domains and... Cell-specific retroviral vectors with antibody domains and...

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01) A61K 48/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2311602

The invention relates to cell-specific retroviral vectors with antibody recognition domains (scFv), which are suitable for cell-specific transduction of a selected mammal cell type (cell targeting), to methods for the production of the cell-specific retroviral vectors and to the use thereof in gene transfers into selected cells. The invention further relates to retroviral packaging cells to obtain cell-specific retroviral vectors according to the present invention.

Vecteurs rétroviraux à spécificité cellulaire, dotés de domaines de reconnaissance d'anticorps (scFv), qui sont appropriés pour la transduction à spécificité cellulaire d'un type choisi de cellules de mammifère (ciblage cellulaire), procédés de fabrication desdits vecteurs et leur utilisation pour le transfert de gènes dans des cellules choisies. La présente invention concerne en outre des cellules d'encapsidation rétrovirales destinées à obtenir les vecteurs rétroviraux à spécificité cellulaire selon la présente invention.

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