Pharmaceutical compositions containing a bile salt and a...

A - Human Necessities – 61 – K

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A61K 47/28 (2006.01) A61K 38/23 (2006.01) A61K 38/28 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2198721

Compositions containing a bile salt and a buffer such as a carbonate or bicarbonate salt which is adapted to buffer the gut to a pH of from 7.5 to 9 are capable of increasing the bioavailability of an active molecule whilst minimising the toxic side effects which are generally associated with bile salts.

L'invention concerne des compositions qui, contenant un sel biliaire et un tampon, un sel carbonate ou un sel de bicarbonate par exemple, propre à ajuster le pH du tractus digestif entre 7,5 et 9, sont susceptibles d'accroître la biodisponibilité d'une molécule active tout en réduisant au maximum les effets secondaires toxiques généralement associés à l'administration de sels biliaires.

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