Novel reovirus-derived proteins, nucleic acids encoding...

Details Novel reovirus-derived proteins, nucleic acids encoding... Novel reovirus-derived proteins, nucleic acids encoding...

C - Chemistry, Metallurgy

12

N

C12N 15/46 (2006.01) A61K 9/127 (2006.01) C07K 14/14 (2006.01) C07K 16/10 (2006.01) C12N 5/12 (2006.01) C12N 5/16 (2006.01) C12N 15/02 (2006.01) C12N 15/88 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2310213

In accordance with the present invention, viral proteins that are responsible for membrane fusion and syncytium formation induced by three different fusogenic orthoreoviruses, i.e., avian reoviruses (ARV), Nelson Bay virus (NBV), and Baboon Reovirus (BRV), have been identified. The genes encoding these proteins have been cloned and sequenced; functional analysis thereof indicates that expression of these proteins in transfected cells results in cell-cell fusion.

Selon la présente invention, les protéines vitales qui sont responsables de la fusion membranaire et de la formation de syncytium induite par trois orthoréovirus fusogéniques différents, à savoir les réovirus aviaires (ARV), le virus de Belson Bay (NBV) et le réovirus du babouin (BRV), ont été identifiées. Les gènes codant pour ces protéines ont été clonés et séquencés; leur analyse fonctionnelle fait apparaître que l'expression de ces protéines dans les cellules transfectées conduit à une fusion cellule-cellule.

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