B - Operations – Transporting – 65 – D
Patent
B - Operations, Transporting
65
D
B65D 81/38 (2006.01) A61J 1/16 (2006.01) F25D 3/08 (2006.01) G01N 1/42 (2006.01)
Patent
CA 2078143
Disclosed are shipping and/or storage units (10) for containers (11) of liquid compositions, such as solutions of biological- ly active proteins, which are susceptible to physicochemical change upon freezing. Preferred container holders have double side- walls (12, 13) and a freeze indicator (16) adjacent a container-accommodating cavity (14). A phase change material (22) such as a carboxymethylcellulose gel is disposed in the enclosed space between sidewalls (18) and freezes at a temperature higher than the nucleation temperature of the composition. A freeze indicator (16) provides an irreversible visual signal upon reaching a tempera- ture intermediate the nucleation temperature of the liquid composition and the freezing temperature of the phase change material (22).
Cleary Kenneth M. Jr.
Schea Henry E. III
Amgen Inc.
Ridout & Maybee Llp
LandOfFree
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