Redox reversible hcv proteins with native-like conformation

Details Redox reversible hcv proteins with native-like conformation Redox reversible hcv proteins with native-like conformation

C - Chemistry, Metallurgy

07

K

C07K 14/18 (2006.01) A61K 39/29 (2006.01) A61P 31/14 (2006.01) C07K 16/10 (2006.01) C12N 15/51 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2387666

The present invention relates to HCV proteins in which cysteine residues are reversibly protected during purification. Eventually, this purification procedure results in HCV proteins with biological activity and a native-like protein conformation, which present corresponding epitopes. The present invention pertains also to drug screening methods using these HCV proteins, and diagnostic and therapeutic applications, such as vaccines and drugs.

La présente invention concerne des protéines HCV dans lesquelles les résidus de cystéine sont protégés de façon réversible durant la purification. Cette procédure de purification donne finalement des protéines HCV qui présentent une activité biologique, une conformation protéinique de type endogène et des épitopes correspondants. Cette invention concerne aussi des techniques de recherche de médicament utilisant ces protéines HCV, et des applications diagnostiques et thérapeutiques, telles que des vaccins et des médicaments.

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