Piperazine d3 and 5-ht2a receptor modulators

Details Piperazine d3 and 5-ht2a receptor modulators Piperazine d3 and 5-ht2a receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 261/20 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2735400

The present invention relates to compounds of the general formula (I) (I) wherein X, n and R1 are as described herein, as well as pharmaceutically acceptable salts and esters thereof, as well as their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are dual modulators of the serotonin 5-HT2. and dopamine D3 receptors, useful in the treatment and/or the prevention of cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and psychoses comprising paranoia and delusions.

La présente invention porte sur des composés représentés par la formule générale (I) (I) dans laquelle X, n et R1 sont tels que décrits dans la description, ainsi que sur des sels et esters pharmaceutiquement acceptables de ceux-ci, ainsi que sur leur fabrication, sur des compositions pharmaceutiques les contenant et sur leur utilisation comme médicaments. Les composés actifs de la présente invention sont des modulateurs doubles des récepteurs sérotoninergique 5-HT2a et dopaminergique D3, utiles dans le traitement et/ou la prévention de troubles cognitifs, de la toxicomanie, de la dépression, de l'anxiété, de la pharmacodépendance, de démences, d'un affaiblissement de la mémoire, de troubles psychotiques comprenant la schizophrénie, les troubles schizo-affectifs, un trouble bipolaire, une manie, la dépression psychotique et les psychoses comprenant la paranoïa et les délires.

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