C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/10 (2006.01)
Patent
CA 2749301
Described are novel compounds of the Formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol, triglyceride levels; treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis, rheumatoid arthritis; treat-ment and/or prophylaxis of type II diabetes. These compounds are more particularly dipeptidyl peptidase (DPP IV) inhibitors.
La présente invention concerne de nouveaux composés de formule (I), ainsi que les dérivés, analogues, formes tautomères, régioisomères, stéréoisomères, polymorphes, solvates, intermédiaires, sels pharmaceutiquement acceptables, compositions pharmaceutiques, métabolites et promédicaments de ceux-ci. Ces composés sont efficaces pour abaisser la glycémie, les taux d'insuline sérique, d'acides gras libres, de cholestérol, de triglycérides. Ils sont également efficaces dans le traitement de l'obésité, de l'inflammation, de maladies auto-immunes telles que la sclérose en plaques, la polyarthrite rhumatoïde, et dans le traitement et/ou la prophylaxie du diabète de type II. Ces composés sont plus particulièrement des inhibiteurs de dipeptidyl peptidase (DPP-IV).
Balasubramanian Gopalan
Balasubramanian Jeganatha Sivakumar
Dharmalingam Sivanesan
Kulathingal Jayanarayan
Mookkan Jeyamurugan
Gowling Lafleur Henderson Llp
Orchid Research Laboratories Limited
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