Synthetic peptides and uses thereof for the prevention and...

Details Synthetic peptides and uses thereof for the prevention and... Synthetic peptides and uses thereof for the prevention and...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) C07K 7/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2472775

The present invention relates to synthetic peptides of the invention comprises PRKPKWDK (SEQ ID: 2) peptide corresponding to amino acids of 85 to 92 of the matrix metalloproteinase (MMP-2), and fragments, analogs and homologs to SEQ ID:2). The invention also relates to the uses of such peptides as inhibitory of human cancer invasion and metastasis and further to the therapeutic use in preventing and and treating cancer and other pathological conditions related to the degradation of extracellular matrix by MMPs.

Cette invention a trait à des peptides de synthèse comprenant un peptide PRKPKWDK (SEQ ID: 2) correspondant aux acides aminés 85 à 92 de la métalloprotéinase matrice (MMP-2), ainsi que des fragments, des analogues et des homologues de la séquence SEQ ID:2. L'invention porte également sur l'utilisation de ces peptides comme agents d'inhibition de cancers envahissants et de métastases ainsi que sur leur utilisation thérapeutique s'agissant de prévention et de traitement de cancers et d'autres états pathologiques, liés à la détérioration de la matrice extracellulaire par des MMP.

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