Substituted cyclohexane derivatives

Details Substituted cyclohexane derivatives Substituted cyclohexane derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/18 (2006.01) A61K 31/18 (2006.01) A61K 31/325 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07C 271/48 (2006.01) C07C 271/52 (2006.01) C07C 311/17 (2006.01) C07D 207/09 (2006.01) C07D 211/34 (2006.01)

Patent

CA 2468879

The present invention relates to compounds of formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, U, V, W, m, n and p are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

L'invention concerne des composés représentés par la formule (I), dans laquelle A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, A?7¿, A?8¿, A?9¿, A?10¿, U, V, W, m, n et p sont définis dans la description et les revendications, ainsi que des sels pharmaceutiquement acceptables de ces composés. Ces composés sont utiles pour le traitement et/ou la prévention de maladies associées à la 2,3-oxydosqualène-lanostérol cyclase, telles que l'hypercholestérolémie, l'hyperlipémie, l'artériosclérose, les maladies vasculaires, les mycoses, les infections parasitaires, les calculs biliaires, les tumeurs et/ou les troubles hyperprolifératifs, et pour le traitement et/ou la prévention de l'intolérance au glucose et du diabète.

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