C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 239/70 (2006.01)
Patent
CA 2698018
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.
La présente invention propose des composés tricycliques ayant une activité cytostatique et cytotoxique en une seule molécule ayant une activité d'inhibition du récepteur de la ou des tyrosine kinase(s), de la dihydrofolate réductase, de la thymidylate synthase et/ou de la dihydroorotate déhydrogénase, qui s'utilisent en tant qu'agents anti-angiogenèses et anti-tumoraux. L'invention propose également des procédés d'utilisation de ces inhibiteurs pour traiter des cellules tumorales et d'autres maladies et troubles prolifératifs.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Duquesne University Of The Holy Ghost
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