C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/02 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/36 (2006.01) C12N 1/21 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2454731
The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment
La présente invention concerne des procédés et des compositions d'expression et de production d'anticorps de recombinaison dans un système de cellules hôtes, tel que des systèmes d'expression procaryotiques et eucaryotiques. L'invention concerne notamment des systèmes de recombinaison d'expression temporellement séparée de chaîne légère et de chaîne lourde d'anticorps. Les produits d'anticorps tels que des fragments d'anticorps peuvent être employés dans différents domaines de la recherche biologique, du diagnostic et du traitement médical.
Andersen Dana C.
Simmons Laura C.
Genentech Inc.
Smart & Biggar
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