Quinazolines as inhibitors of hiv reverse transcriptase

Details Quinazolines as inhibitors of hiv reverse transcriptase Quinazolines as inhibitors of hiv reverse transcriptase

C - Chemistry, Metallurgy

07

D

C07D 239/80 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2095194

206/RDM103 18727IA TITLE OF THE INVENTION NEW QUINAZOLINES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE ABSTRACT OF THE DISCLOSURE Compounds having a quinazolin-2-one nucleus with a substituted alkynyl or substituted alkenyl at the 4-position are described. These compounds are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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