C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/46 (2006.01) A61K 31/445 (2006.01) A61K 31/4525 (2006.01) A61K 31/453 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61K 31/4709 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2667511
The present invention relates to dual modulators of the serotonin 5-HT2a and dopamine D3 receptors which are represented by the general formula (I) wherein R1, R2 and A are as defined in the specification, to a process for the manufacture thereof, as well as to pharmaceutically acceptable salts thereof for the manufacture of a medicament for the treatment or prevention of cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and psychoses comprising paranoia and delusions.
La présente invention concerne des modulateurs doubles des récepteurs de sérotonine 5-HT2a et de dopamine D3, qui sont représentés par la formule générale (I), dans laquelle R1, R2 et A sont tels que définis dans la description, leur procédé de fabrication, ainsi que leurs sels pharmaceutiquement acceptables pour la fabrication d'un médicament pour le traitement ou la prévention de troubles cognitifs, de la toxicomanie, de la dépression, de l'anxiété, de la dépendance aux médicaments, de la démence, de la déficience de la mémoire, des troubles psychotiques, notamment la schizophrénie, les troubles schizoaffectifs, les maladies bipolaires, les manies, la dépression psychotique, et des psychoses, notamment la paranoïa et les illusions.
Gobbi Luca Claudio
Jaeschke Georg
Roche Olivier
Rodriguez Sarmiento Rosa Maria
Steward Lucinda
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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