C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61P 31/00 (2006.01) C07K 1/107 (2006.01) C07K 14/00 (2006.01) C12N 9/10 (2006.01) C12N 15/10 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2490290
A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to- tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
L'invention porte sur un procédé de production d'un polypeptide dont l'activité ou la stabilité a été modifiée. Ce procédé consiste à remplacer un reste d'arginine pouvant être ribosylé par ADP par un tryptophane ou une phénylalanine. Selon un mode de réalisation, on produit des compositions qui comprennent des polypeptides tels que la défensine alpha, avec des substitutions arginine par tryptophane ou arginine par phénylalanine, le reste d'arginine pouvant être ribosylé par ADP. Selon un autre mode de réalisation, l'invention porte sur des procédés de modification d'une réponse immune chez un sujet.
Bortell Rita
Bourgeois Christelle
Moss Joel
Stevens Linda
Smart & Biggar
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
University Of Massachusetts Medical Center
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