A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/765 (2006.01) A61K 31/22 (2006.01)
Patent
CA 2071094
ABSTRACT An inhibiting agent against the proliferation of malignant tumor cells of animals including human beings which comprises a mixture of an L-lactic acid straight-chain condensate having a degree of condensation of 5 to 23 and an L-lactic acid cyclic condensate having a degree of condensation of 2 to 15, which mixture is obtained by heating lactic acid under normal pressures or reduced pressure in an atmosphere of an inert gas such as nitrogen gas, distilling off the water present in the monomer first and then the moisture produced in the condensation reaction out of the reaction system, dissolving and dispersing the obtained lactic acid low condensates in methanol, equilibrating the dispersion in an atmosphere having a certain temperature followed by filtration, drying the methanol solution under reduced pressure, dissolving the residue in acetonitrile, passing the solution through a reverse phase system ODS column which has previously been equilibrated by using a 10 to 20 % acetonitrile solution having a pH of 2 to 3 wherein the acetonitrile concentration is increased successively to carry out stepwise elution, and collecting a fraction eluted with an acetonitrile solution having an acetonitrile concentration of 30 to 50 % and a pH of 2 to 3, and its manufacture.
Iijima Kunihito
Kato Haruki
Nagasu Yoichiro
Koken Co. Ltd.
Marks & Clerk
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