Novel oxazole and thiazole compounds as transforming growth...

Details Novel oxazole and thiazole compounds as transforming growth... Novel oxazole and thiazole compounds as transforming growth...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61P 35/00 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 419/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2499429

Novel thiazole derivatives of formula I a - c, intermediates fo their preparation, pharmaceutical compositions containing them and their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-.beta.signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

L'invention porte sur de nouveaux composés de triazole et d'oxazole, leurs dérivés, leurs intermédiaires de préparation, des préparations pharmaceutiques les contenant, et leurs utilisations médicales. Lesdits composés, qui sont de puissants inhibiteurs du mécanisme de signalisation du facteur de croissance transformant (<=TGF>=)-.beta., s'avèrent utiles pour le traitement de différentes maladies liées au TGF dont par exemple le cancer et les troubles fibrogènes.

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