A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) C07D 239/47 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2447020
This invention relates to 4-aminopyrimidine derivatives of the general formula (I) wherein R1, R2, R3 and R4 have the signifiances defined in the specification and their pharmaceutically acceptable salts. The invention further relates to the preparation of such compounds, to medicaments containing such compounds and to their use for the prevention or treatment of mGluR5 receptor mediated disorders.
L'invention concerne des dérivés de 4-aminopyrimidine représentés par la formule (I) dans laquelle R<1>, R<2>, R<3> et R<4> sont tels que décrits dans le descriptif, et leurs sels acceptables sur le plan pharmaceutique. L'invention concerne par ailleurs la préparation de ces composés, des médicaments contenant ces composés ainsi que leur utilisation pour prévenir ou traiter les troubles induits par le récepteur mGluR5.
Mutel Vincent
Peters Jens-Uwe
Wichmann Juergen
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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