C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2566332
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, wherein R1-R4 and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
L'invention concerne un composé de formule (I), ou un sel, un solvate, un hydrate ou un promédicament pharmaceutiquement acceptable de celui-ci, dans laquelle R?1¿-R?4¿ et Ar sont tels que définis dans le descriptif. Ces nouveaux dérivés pyrimidiques sont utilisés dans le traitement de la croissance de cellules anormales, telles que les cellules cancéreuses, chez les mammifères. Par ailleurs, l'invention concerne un procédé d'utilisation de ces composés dans le traitement de la croissance des cellules anormales chez les mammifères, en particulier les humains, ainsi que des compositions pharmaceutiques qui renferment ces composés.
Kath John Charles
Luzzio Michael Joseph
Pfizer Products Inc.
Sim & Mcburney
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