Treatment of sepsis-induced acute renal failure and renal...

Details Treatment of sepsis-induced acute renal failure and renal... Treatment of sepsis-induced acute renal failure and renal...

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/00 (2006.01) A61K 31/4174 (2006.01)

Patent

CA 2259449

Methods are provided for treating sepsis/endotoxin-induced acute renal failure, and renal vasoconstriction and catecholamine-induced renal and mesenteric vasoconstriction by administering to a patient a therapeutically effective amount of a composition comprising at least one drug with Type IV phosphodiesterase inhibiting activity or any combination thereof and a pharmaceutically acceptable carrier.

L'invention concerne des méthodes qui permettent de traiter l'insuffisance rénale aiguë d'origine septique/endotoxinique, ainsi que la vasoconstriction rénale et mésentérique provoquée par les catécholamines. Ces méthodes consistent à administrer à un patient une dose thérapeutique efficace d'une composition qui contient au moins un médicament ayant une activité inhibitrice de la phosphodiestérase de type IV, ou une combinaison de celle-ci avec un excipient pharmaceutiquement acceptable.

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