Topiramate analogs

Details Topiramate analogs Topiramate analogs

C - Chemistry, Metallurgy

07

H

C07H 11/00 (2006.01) C07H 9/02 (2006.01) G01N 33/531 (2006.01) A61K 39/385 (2006.01) C07K 14/435 (2006.01) C07K 14/765 (2006.01)

Patent

CA 2586466

Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies.

La présente invention concerne généralement des analogues de topiramate qui comprennent des substituants au niveau du groupe sulfamate ou aux positions 9 ou 10. Les analogues de topiramate peuvent comprendre des fragments immunogènes pouvant être utilisés pour préparer des anticorps anti-topiramate, ou des fragments antigéniques pouvant être utilisés dans des dosages d'immunodiagnostic pour le topiramate. Les analogues de topiramate peuvent également comprendre des fragments de marquage destinés à détecter la présence ou la quantité de l'analogue au cours d'un dosage d'immunodiagnostic. Les analogues de topiramate peuvent en outre être utilisés dans des dosages d'immunodiagnostic pour concurrencer le topiramate pour la liaison avec des anticorps anti-topiramate.

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