C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C12N 5/10 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2156728
The invention relates to a nucleic acid sequence, called "polyribozyme", which has an endoribonuclease activity and is capable of inactivating the gene for the capsid protein of a virus, characterized in that it comprises : i) a sequence complementary to at least a part of the gene or its transcript or to its replication intermediates and, includes at distinct sites in this complementary sequence : ii) a plurality of ribozyme catalytic regions; iii) and, optionally, one or more sequences non- complementary to the transcript of the said gene, the said non-complementary sequence(s) being inserted between two consecutive bases of the complementary sequence.
Baudot Gaelle
Gruber Veronique
Lenee Philippe
Ollivo Catherine
Perez Pascual
Gene Shears Pty. Ltd.
Sim & Mcburney
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