Thionucleosides and pharmaceutical applications

Details Thionucleosides and pharmaceutical applications Thionucleosides and pharmaceutical applications

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/695 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01) C07H 19/06 (2006.01) C07H 19/067 (2006.01) C07H 19/073 (2006.01)

Patent

CA 2667569

The invention relates to a pharmaceutical composition containing as an active ingredient at least one compound selected from the compounds of the formula (II), in which the S atom is bonded to the nucleoside carbon at T or to the nucleoside carbon at 3', and from the compounds of the following formula (III): formulae in which B is a nucleotide natural or modified base, x is 0, 1 or 2, and R1 and R represent a carbonated group or a molecular hydrocarbon remnant that can be substituted and/or interrupted by one or more atoms and/or by one or more groups containing one or more atoms, said atoms being selected from N, O, P, S, Si, X where X is halogen. The invention also relates to pharmaceutically acceptable carrier.

L'invention concerne une composition pharmaceutique comprenant, à titre de principe actif, au moins un composé choisi parmi les composés répondant à la formule (II) suivante: où l'atome S est lié au carbone en T ou au carbone en 3 ' du nucléoside, et les composés répondant à la formule (III) suivante : formules dans lesquelles B représente une base nucléotidique, naturelle ou modifiée, x est égal à O, 1 ou 2, et Rl, R représentent un groupement carboné ou un reste moléculaire hydrocarboné pouvant être substitué et/ou interrompu par un ou des atomes et/ou par un ou des groupements comprenant un ou des atomes, lesdits atomes étant choisis parmi N, O, P, S, Si, X où X représente un halogène, et un excipient pharmaceutiquement acceptable.

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