Phosphonates and parathyroid hormone for osteoporosis

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 31/66 (2006.01) A61K 38/29 (2006.01)

Patent

CA 2199251

The present invention provides methods of treating a human or other animal subject having a bone metabolism disorder, comprising the steps of: (a) administering to said subject a safe and effective amount of an antiresorptive compound during a period of from about 2 weeks to about 6 months; (b) administering to said subject a safe and effective amount of a parathyroid hormone, during a period of from about 3 to about 12 months. Preferred antiresorptive compounds include bisphosphonates, estrogen compounds, and antiestrogen compounds.

Méthodes de traitement d'un sujet humain ou animal présentant un trouble du métabolisme osseux, comportant les étapes suivantes : a) administration audit sujet d'une quantité sûre et efficace d'un composé inhibiteur de la résorption osseuse durant une période allant d'environ 2 semaines à environ 6 mois; b) administration audit sujet d'une quantité sûre et efficace d'une parathormone, durant une période d'environ 3 à environ 12 mois. Les composés d'élection pour l'inhibition de la résorption sont les diphosphonates, les composés d'estrogènes et les composés d'antiestrogènes.

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