Renin inhibitors for the prevention and treatment of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/165 (2006.01) A61K 31/445 (2006.01) A61K 31/549 (2006.01) A61K 45/06 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2672579

The present invention relates to methods for the prevention of, delay progression to or treatment of hypertension in obese patients, comprising administering to a warm-blooded animal a therapeutically effective amount of a renin inhibitor such as aliskiren or a pharmaceutically acceptable salt. The renin inhibitor may be used alone or in combination with another antihypertensive agent, in particular a diuretic such as hydrochlorothiazide.

La présente invention concerne des procédés de prévention, de retard de progression ou de traitement de l'hypertension chez des patients obèses, comprenant l'administration à un animal à sang chaud d'une quantité thérapeutiquement efficace d'un inhibiteur de rénine tel que l'aliskirène ou d'un sel pharmaceutiquement acceptable. L'inhibiteur de rénine peut être utilisé seul ou en combinaison avec un autre antihypertenseur, en particulier un diurétique tel que l'hydrochlorothiazide.

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