Surface-layer protein coated microspheres and uses thereof

Details Surface-layer protein coated microspheres and uses thereof Surface-layer protein coated microspheres and uses thereof

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 38/17 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2676483

The invention provides surface-layer protein coated microspheres for delivery of a therapeutic agent to the intestine. These surface-layer protein coated microspheres generally include a core encapsulated by a microsphere which is coated by surface layer protein. The core includes a therapeutic agent, such as a defensin. The invention also includes methods of making and using the surface-layer protein coated microspheres of the invention for administering therapeutic agents to a subject in need thereof. The invention also includes pharmaceutical dosage units that include the surface-layer protein coated microspheres of the invention. The invention further includes various labeled defensins for use in the study of the properties and actions of defensins, and further includes the use of defensins, particularly HD5.alpha. in the treatment of inflammatory conditions of the bowel, such as Crohn's disease.

L'invention concerne des microsphères enrobées d'une protéine de couche superficielle destinées à administrer un agent thérapeutique au niveau de l'intestin. Ces microsphères enrobées d'une protéine de couche superficielle comprennent en général un noyau encapsulé par une microsphère qui est enrobée par une protéine de couche superficielle. Le noyau comprend un agent thérapeutique tel qu'une défensine. L'invention comprend également des procédés de fabrication et d'utilisation des microsphères enrobées d'une protéine de couche superficielle de l'invention en vue d'administrer des agents thérapeutiques à un patient. L'invention concerne également des unités galéniques qui comprennent les microsphères enrobées d'une protéine de couche superficielle selon l'invention. Cette dernière concerne en outre diverses défensines marquées destinées à une utilisation dans l'étude des propriétés et des actions des défensines, ainsi que l'utilisation de celles-ci, notamment de HD5.alpha. dans le traitement de pathologies inflammatoires de l'intestin telles que la maladie de Crohn.

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